LORANTHUS MICRANTHUS LINN AQUEOUS LEAF EXTRACT EXHIBITED PROTECTION AGAINST TISSUE DAMAGE BY PARACETAMOL TOXICITY IN MALE WISTAR RATS
The protective effect of aqueous extract of Loranthus micranthus Linn leaf against paracetamol toxicity in male Wistar rats was investigated. Twenty male Wistar rats were randomly assigned into four (4) groups of five (5) animals each. One group served as control; another group was administered 150 mg/kg of the plant extract. Paracetamol (400 mg/kg) was administered alone to one of the groups while another group received 400 mg/kg of paracetamol co-administered with 150 mg/kg of the plant extract. The last group received 400 mg/kg of paracetamol co-administered with 100 mg/kg of vitamin C. The experiment lasted for 28 days and various biochemical assays were investigated. Paracetamol increased (p<0.05) the activities of ALT, AST and ALP in plasma while concentrations of albumin and total protein were significantly (p<0.05) decreased. Creatinine and urea concentrations were also significantly (p<0.05) increased in plasma. Catalase (CAT) and superoxide dismutase (SOD) activities, as well as reduced glutathione (GSH) levels in the liver and kidney homogenates were significantly (p<0.05) decreased while malondialdehyde level was significantly (p<0.05) increased. These alterations were significantly ameliorated by 150 mg/kg of the plant extract and 100 mg/kg of vitamin C. These findings suggest that aqueous leaf extract of L. micranthus can confer protection against tissue damage by paracetamol toxicity in male Wistar rats.