UTEROTONIC EVALUATION OF CROTON LOBATUS LINN ON REPRODUCTIVE PARAMETERS OF WISTAR RATS
Croton lobatus belongs to the crotonoideae family which comprises of 1300 species. The plant possesses some biological properties and its used ethno medicinally. The plant has been active as antimicrobial, anti-parasitic agents, anti-ulcer and anti-cancer agents. The Histological and Uterotonic evaluation of C. lobatus on the reproductive parameters of matured female Wister rats was carried out. Four groups of six rats each received the extracts, at four oral doses 0, 200, 400 and 1000 mg /kg/wt. administered orally for a period of 21 days. The dissected ovaries were weighed and studied histologically. Uterotonic assay was also carried out. The results obtained histologically revealed that the extract of C. lobatus was safe at 200, 400 and 1000 mg/kg/wt. The extract acted as fertility booster, since there was increased growth of follicles leading to the production of secondary follicles and oocytes in the ovary on the uterus, the extract was seen to have cursed relaxation on the uterine smooth muscles. Therefore, C. lobatus leaves favoured reproductive parameters been a tocolytic agent, thus
supporting the use of the aqueous leave extract in the prevention of threatened abortion, management of pregnancy and infertility.