THE ANTI-DIARRHOEA EFFECT OF COMBRETUM PLATYPTERUM (WELW) HUTCH & DALZIEL AND COMBRETUM RACEMOSUM P. BEAWV IN MICE AND RATS
Plant has always been a common source of medicine, either as active principles or traditional preparation. Combretum platypterum and Combretum racemosum belong to the family of Combretaceae. It is used to treat lower backache, fever, eye problems, malaria, swellings and mumps, conjunctivitis, coughs, sexually
transmitted diseases, helminthiasis and diarrhoea. This study aimed at testing the anti-diarrhoea effect of aqueous leaf extract of Combretum platypterum and Combretum racemosum. Antidiarrhoea activity was carried out using Castor-Oil induced Diarrhea, Gastro-intestinal motility test and Castor oil Induced Enteropooling test. 8 groups of 4 rats per group. Group 1 Received distilled water (10ml/kg P. O), group2 Received Loperamide (1mg/kg I. P). Group 2 to 3 Received 100, 200 and 400mg/kg aqueous leaf extract of Combretum platypterum, O.P. Group 6 to 8 Received 100, 200 and 400mg/kg aqueous leaf extract of Combretum platypterum, O.P. In Castor-Oil induced diarrhea, the mean numbers of faceces were reduced at all dose level of aqueous leaf extract of C.
platypterum and the leaf extract of C. racemosum reduced the number of diarrheal faeces at 200 mg/kg. C. platypterum in Gastro-intestinal motility test animal model, shows a significant intestinal motility inhibition at all dose level and C. racemosum at 400mg/kg of the leaf extract reduced the percentage travel by charcoal compared to control. In Castor oil induced enteropooling, C. platypterum has no effect on weight volume of intestinal content and C. racemosum at 100 mg/kg, 200 mg/kg, 400 mg/kg and loperamide (1mg/kg) were significant in reducing the weight of intestinal content. Combretum platypterum and C. racemosum posses’ anti-diarrhoea activity.